×
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
Intervertebral Disc Degeneration
0.360
Biomarker
BEFREE
This study suggests that TGF-β1 may be effective to retard inflammation-mediated disc degeneration .
31808511 2020
×
Entrez Id: 7421
Gene Symbol: VDR
VDR
Intervertebral Disc Degeneration
0.100
GeneticVariation
BEFREE
Association of vitamin D receptor gene polymorphisms with disc degeneration .
31768839 2020
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Intervertebral Disc Degeneration
0.030
Biomarker
BEFREE
The PI3K ‑AKT signaling pathway, advanced glycation endproducts‑receptor for advanced glycation endproducts signaling pathway, p53 signaling pathway, and transforming growth factor‑b signaling pathway were activated in disc degeneration .
31746390 2020
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Intervertebral Disc Degeneration
0.030
Biomarker
BEFREE
The PI3K ‑AKT signaling pathway, advanced glycation endproducts‑receptor for advanced glycation endproducts signaling pathway, p53 signaling pathway, and transforming growth factor‑b signaling pathway were activated in disc degeneration .
31746390 2020
×
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
Intervertebral Disc Degeneration
0.030
Biomarker
BEFREE
The PI3K ‑AKT signaling pathway, advanced glycation endproducts‑receptor for advanced glycation endproducts signaling pathway, p53 signaling pathway, and transforming growth factor‑b signaling pathway were activated in disc degeneration .
31746390 2020
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Intervertebral Disc Degeneration
0.030
Biomarker
BEFREE
The PI3K ‑AKT signaling pathway, advanced glycation endproducts‑receptor for advanced glycation endproducts signaling pathway, p53 signaling pathway, and transforming growth factor‑b signaling pathway were activated in disc degeneration .
31746390 2020
×
Entrez Id: 2965
Gene Symbol: GTF2H1
GTF2H1
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
However, p62 increased progressively with increasing disc degeneration grade.
31802633 2020
×
Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
However, p62 increased progressively with increasing disc degeneration grade.
31802633 2020
×
Entrez Id: 10725
Gene Symbol: NFAT5
NFAT5
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
TonEBP -deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression.31707045 2020
MIR181A2
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
MicroRNA-181a exerts anti-inflammatory effects via inhibition of the ERK pathway in mice with intervertebral disc degeneration .31508816 2020
×
Entrez Id: 10657
Gene Symbol: KHDRBS1
KHDRBS1
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
However, p62 increased progressively with increasing disc degeneration grade.
31802633 2020
×
Entrez Id: 51164
Gene Symbol: DCTN4
DCTN4
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
However, p62 increased progressively with increasing disc degeneration grade.
31802633 2020
×
Entrez Id: 23636
Gene Symbol: NUP62
NUP62
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
However, p62 increased progressively with increasing disc degeneration grade.
31802633 2020
×
Entrez Id: 3920
Gene Symbol: LAMP2
LAMP2
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
LAMP2 rose with increasing disc degeneration grade through grade V. In the quantitative analysis of colocalization, grade III is significantly higher than grade II and V (P < 0.05).31802633 2020
×
Entrez Id: 57103
Gene Symbol: TIGAR
TIGAR
Intervertebral Disc Degeneration
0.010
Biomarker
BEFREE
TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy.31317559 2020
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Intervertebral Disc Degeneration
0.100
Biomarker
BEFREE
Apoptosis in nucleus pulposus (NP) cells which induced by TNF-α has been widely known to associate with the disc degeneration .
31322007 2019
×
Entrez Id: 176
Gene Symbol: ACAN
ACAN
Intervertebral Disc Degeneration
0.100
Biomarker
BEFREE
Within this scope, we discuss the current knowledge concerning the structure and function of aggrecan in intervertebral disc degeneration .
29992840 2019
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Intervertebral Disc Degeneration
0.100
Biomarker
BEFREE
To investigate the role of IL-1 in driving age-related disc degeneration , we studied the spine phenotype of global IL-1α/β double knockout (IL-1KO) mice at 12 and 20 months.
30875127 2019
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Intervertebral Disc Degeneration
0.100
Biomarker
BEFREE
IL-6 /YAP1/β-catenin signaling is involved in intervertebral disc degeneration .30511395 2019
×
Entrez Id: 176
Gene Symbol: ACAN
ACAN
Intervertebral Disc Degeneration
0.100
Biomarker
BEFREE
The content of lactic acid gradually increased after annular lesion, associated with the damage of AF structural and the decrease of Col -II and aggrecan in NP tissue, which leading to the disc degeneration .
31747924 2019
×
Entrez Id: 7421
Gene Symbol: VDR
VDR
Intervertebral Disc Degeneration
0.100
AlteredExpression
BEFREE
Our study demonstrated that decreased expression of VDR may play a role in age-related intervertebral disc degeneration in rats and that activation of VDR ameliorates oxidative stress-induced apoptosis in AF cells by preserving mitochondrial functions.
30905826 2019
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Intervertebral Disc Degeneration
0.100
AlteredExpression
BEFREE
In addition, nucleus pulposus cells stimulated with interleukin-1β (IL-1β ) expressed less SIRT3 than that in the control group and nucleus pulposus cells with SIRT3 overexpress vectors expressed more collagen II FOXO3a and superoxide dismutase 2 (SOD2), indicating that SIRT3 could improve the intervertebral disc degeneration by anti-oxidative stress.
31773668 2019
×
Entrez Id: 176
Gene Symbol: ACAN
ACAN
Intervertebral Disc Degeneration
0.100
Biomarker
BEFREE
The in vivo experiments showed that the HIF-2α controlled the catabolic factors MMP-13 and ADAMTS-4 that regulated the collagen II and aggrecan metabolism in disc degeneration .
31251999 2019
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Intervertebral Disc Degeneration
0.100
Biomarker
BEFREE
Melatonin modulates IL-1β -induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation.
31772145 2019
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Intervertebral Disc Degeneration
0.100
Biomarker
BEFREE
Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo.
30785069 2019